2-Bromomethyl-isonicotinic acid methyl ester

2-Bromomethyl-isonicotinic acid methyl ester - Names and Identifiers

Name	methyl 2-(bromomethyl)pyridine-4-carboxylate
Synonyms	LogP Methyl2-(bromomethyl)isonicotinate Methyl 2-(bromomethyl)isonicotinate 4-Pyridinecarboxylic acid, 2-(bromomethyl)- methyl 2-(bromomethyl)pyridine-4-carboxylate 2-Bromomethyl-isonicotinic acid methyl ester 2-(broMoMethyl)-4-Pyridinecarboxylic acid, Methyl ester 4-PYRIDINECARBOXYLIC ACID, 2-(BROMOMETHYL)-, METHYL ESTER 4-pyridinecarboxylic acid, 2-(bromomethyl)-, methyl ester Methyl 2-(bromomethyl)pyridine-4-carboxylate, 2-(Bromomethyl)-4-(methoxycarbonyl)pyridine
CAS	914639-05-7
InChI	InChI=1/C8H8BrNO2/c1-12-8(11)6-2-3-10-7(4-6)5-9/h2-4H,5H2,1H3

2-Bromomethyl-isonicotinic acid methyl ester - Physico-chemical Properties

Molecular Formula	C8H8BrNO2
Molar Mass	230.06
Density	1.533g/cm³
Boling Point	294.455°C at 760 mmHg
Flash Point	131.882°C
Vapor Presure	0.002mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.563

2-Bromomethyl-isonicotinic acid methyl ester - Risk and Safety

Hazard Class

IRRITANT

2-Bromomethyl-isonicotinic acid methyl ester - Introduction

methyl 2-(bromomethyl)pyridine-4-carboxylate is an organic compound with the chemical formula C9H8BrNO2.

Nature:
1. Appearance: methyl 2-(bromomethyl)pyridine-4-carboxylate is a white to light yellow solid.
2. Solubility: Soluble in organic solvents such as ethanol, dimethylformamide (DMF), almost insoluble in water.

Use:
methyl 2-(bromomethyl)pyridine-4-carboxylate can be used as an intermediate in organic synthesis. It is often used to synthesize a variety of biologically active compounds, such as pharmaceuticals, pesticides and dyes.

Method:
The preparation of methyl 2-(bromomethyl)pyridine-4-carboxylate usually goes through the following steps:
1. Esterification reaction of 4-picolinic acid with methyl chloroformate in dichloromethane solution to obtain carboxylic acid methyl ester intermediate.
2. in the presence of alkali, methyl bromide is added to the carboxylic acid methyl ester intermediate for bromination reaction to generate methyl 2-(bromomethyl)pyridine-4-carboxylate.

Safety Information:
methyl 2-(bromomethyl)pyridine-4-carboxylate is an organic compound and should be handled with caution. It may be irritating to the skin, eyes and respiratory system, avoid contact with skin and eyes. In use, follow proper laboratory procedures and wear appropriate personal protective equipment, such as lab gloves and goggles. If exposed or inhaled, rinse immediately with plenty of water and seek medical help as soon as possible. The storage and handling of this compound should be carried out in accordance with chemical safety regulations.

Last Update：2024-04-09 15:18:00